منابع مشابه
Genetic susceptibility to lung cancer.
Lung cancer is a highly environmental disease, but cancer researchers have long been interested in investigating genetic susceptibility to lung cancer. This paper is a historical review and provides updated perspectives on lung cancer susceptibility research. The recent introduction of easier genotyping methods and the availability of an almost complete human genome database facilitated the ass...
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To establish a comprehensive picture of the relationship between glutathione S-transferase omega 2 (GSTO2; MIM: 612314) gene N142D variant (rs. 156697) and breast cancer risk, the present meta-analysis was carried out. Studies published up to July 2012 with information about GSTO2 polymorphism and breast cancer risk were identified using several electronic databases. We identified 4 eligible st...
متن کاملGenetic susceptibility to aggressive prostate cancer.
In 2006, f234,460 men in the U.S. will be diagnosed with prostate cancer, and >27,000 deaths will be attributed to the disease (1). There is substantial phenotypic variability among cases and the disease incidence varies by age, race, and family history. In the U.S., f70% of all cases are z65 years at diagnosis, and the median age at diagnosis is 68 years (2). Several types of epidemiologic stu...
متن کاملGenetic susceptibility to cancer. Family physicians' experience.
OBJECTIVE To explore family physicians' experiences in dealing with genetic susceptibility to cancer. DESIGN Qualitative study using focus groups. SETTING Four Ontario sites: northern, rural, urban, and inner city. PARTICIPANTS Forty rural and urban FPs participated in four focus groups: 28 were male; average age was 41. METHOD Focus groups using a semistructured interview guide were au...
متن کاملGenetic susceptibility to triple-negative breast cancer.
Triple-negative breast cancers (TNBC), defined by the absence of estrogen receptor, progesterone receptor, and HER-2 expression, account for 12% to 24% of all breast cancers. TNBC is associated with early recurrence of disease and poor outcome. Germline mutations in the BRCA1 and BRCA2 breast cancer susceptibility genes have been associated with up to 15% of TNBC, and TNBC accounts for 70% of b...
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ژورنال
عنوان ژورنال: JAMA
سال: 2008
ISSN: 0098-7484
DOI: 10.1001/jama.299.20.2423